Gergely Toth - The pathway to DJ-1 based precision therapies for Parkinson's by maintaining cellular redox homeostasis

This talk will explore the critical role of DJ-1 protein in cellular survival, its connection to redox homeostasis, and the implications for ageing-related diseases. Discover how oxidative stress leads to DJ-1 dysfunction, contributing to both familial and sporadic Parkinson’s disease. The session will also cover innovative therapeutic strategies targeting DJ-1, including pharmacological chaperones and enzyme replacement therapies, aimed at combating Parkinson’s. Additionally, learn about the potential of using various oxidized states of DJ-1 as biomarkers for Parkinson’s disease, assessed through novel ELISA techniques. This presentation will be extremely insightful for those interested in the latest advancements in neurodegenerative disease research and therapy.